Common Test-Ordering Errors
Part 5: Overordered Tests
Plasma Thiamin
Serum Folate
Zinc Protoporphyrin (ZPP)
Heme Synthesis*
August 2010
Before blood lead assays were widely available, red blood cell zinc protoporphyrin was used as an indicator of lead toxicity. That test works because lead inhibits several enzymes in the heme synthesis pathway, including the last step, which is catalyzed by the enzyme ferrochetolase. In the presence of lead-induced inhibition, protoporphyrin intermediates accumulates within the RBC; thus, RBC zinc protoporphyrin is a marker for lead toxicity.
Heme Synthesis* |
Jump to section:
- Introduction
- Testing at Mayo Medical Laboratories
- Common MML Test-Ordering Errors
- Overordered Tests
- Thiamin (Vitamin B1)
- Thiamin (Vitamin B1)
- Folate—Serum and RBC
- Diagnostic Algorithm for Macrocytic Anemia
- Simplified Versions of Vitamin-Dependent Pathways
- Lead Toxicity
- Heme Synthesis*
- Laboratory Assessment of Lead Toxicity
- Conclusion
- Questions?
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