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Common Test-Ordering Errors
Part 3: Misordered Tests

"Known" Mutations
Molecular vs. Nonmolecular Test for Given Disease
Chromosome Analysis


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Multiple Endocrine Neoplasia Type 2 (MEN2)

Slide 8

June 2010

Also frequently misordered is the test for multiple endocrine neoplasia type 2 (abbreviated as MEN2)an autosomal dominant cancer syndrome that is characterized by tumors of several different endocrine glands, including medullary carcinoma of the thyroid. For patients with findings suspicious for MEN2, we offer a diagnostic test (“Multiple Endocrine Neoplasia Type 2 Mutation Screen”). We also offer known-mutation testing when a MEN2 mutation has been identified in an affected family member and is used to test other family members for the same mutation. Known-mutation tests are very focused—we look only for the previously identified mutation. Misordering of these 2 tests occurs so frequently that we routinely call to confirm each order. In a recent review of 1 month’s orders, 40% of the tests were ordered incorrectly with the screening test ordered when, in fact, the known-mutation test was indicated.

MEN Type 2


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