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Leukocyte Alkaline Phosphatase Stain (LAP)

Optimizing Laboratory Testing for Hematologic
Disorders Series

LAP: Original Clinical Utility

Slide 7

September 2010

The original clinical utility of LAP was very important in its day. A low LAP score was one of the key recognition criteria for CML and clearly was very helpful in the era before cytogenetic karyotyping became readily available. Conversely, a high LAP score supported the diagnosis of an infectious or bacterial process or as a diagnostic indicator of PV. More importantly, it was used to exclude the diagnosis of CML. Again, this was clearly helpful in the pre‑serum erythropoietin and pre-JAK2 testing era.

LAP: Original Clinical Utility


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