Leukocyte Alkaline Phosphatase Stain (LAP)
Optimizing Laboratory Testing for Hematologic
Disorders Series
LAP: Original Clinical Utility
September 2010
The original clinical utility of LAP was very important in its day. A low LAP score was one of the key recognition criteria for CML and clearly was very helpful in the era before cytogenetic karyotyping became readily available. Conversely, a high LAP score supported the diagnosis of an infectious or bacterial process or as a diagnostic indicator of PV. More importantly, it was used to exclude the diagnosis of CML. Again, this was clearly helpful in the pre‑serum erythropoietin and pre-JAK2 testing era.
LAP: Original Clinical Utility |
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- Introduction
- Optimizing Laboratory Testing for Hematologic Disorders Series
- The Big Picture: We Need to Focus On...
- LAP: A Test That Time Has Passed By
- Abbreviations
- LAP: Assay History
- LAP: Original Clinical Utility
- LAP Procedure—an Inexact Science!
- Typical Staining Type Reaction
- Subjective Nature of the Scoring Process
- LAP Scoring Example
- LAP Discontinued at Mayo Clinic
- Low LAP Scores* Not Specific for CML: A Mayo 1-Year Experience
- Low LAP Scores* Do Not Indicate Myeloid Malignancy: A Mayo 1-Year Experience
- High LAP Scores* Not Specific for PV: A Mayo 1-Year Experience
- High LAP Scores* Do Not Indicate Myeloid Malignancy: A Mayo 1-Year Experience
- LAP: A Test Whose Time Has Passed
- Consequences of an Abnormal LAP
- Alternatives to LAP
- Alternatives to LAP: BCR/ABL
- Alternatives to LAP: JAK2
- Conclusions
- Questions?
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