Leukocyte Alkaline Phosphatase Stain (LAP)
Optimizing Laboratory Testing for Hematologic
Disorders Series
Optimizing Laboratory Testing for Hematologic Disorders Series
September 2010
This is a first in a series of hot topics that will address the issue of appropriate laboratory test utilization in hematologic disorders. This is a combined effort of the Divisions of Hematopathology and Laboratory Genetics with the primary focus of identifying the correct algorithmic testing approach for various hematologic diseases and secondly to demonstrate how the laboratory can and should be engaged in reducing unnecessary testing.
Optimizing Laboratory Testing |
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- Introduction
- Optimizing Laboratory Testing for Hematologic Disorders Series
- The Big Picture: We Need to Focus On...
- LAP: A Test That Time Has Passed By
- Abbreviations
- LAP: Assay History
- LAP: Original Clinical Utility
- LAP Procedure—an Inexact Science!
- Typical Staining Type Reaction
- Subjective Nature of the Scoring Process
- LAP Scoring Example
- LAP Discontinued at Mayo Clinic
- Low LAP Scores* Not Specific for CML: A Mayo 1-Year Experience
- Low LAP Scores* Do Not Indicate Myeloid Malignancy: A Mayo 1-Year Experience
- High LAP Scores* Not Specific for PV: A Mayo 1-Year Experience
- High LAP Scores* Do Not Indicate Myeloid Malignancy: A Mayo 1-Year Experience
- LAP: A Test Whose Time Has Passed
- Consequences of an Abnormal LAP
- Alternatives to LAP
- Alternatives to LAP: BCR/ABL
- Alternatives to LAP: JAK2
- Conclusions
- Questions?
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