Leukocyte Alkaline Phosphatase Stain (LAP)
Optimizing Laboratory Testing for Hematologic
Disorders Series
Alternatives to LAP
September 2010
What are testing alternatives to LAP? Clearly, it depends on the clinical picture. If the patient has an unexplained elevation in counts and/or unexplained splenomegaly, then a myeloproliferative disorder will likely be considered in the differential diagnosis. If CML is a consideration, then BCR/ABL testing is the appropriate route, whereas if PV or other MPNs are in the differential, then JAK2 testing is required.
Alternatives to LAP |
Jump to section:
- Introduction
- Optimizing Laboratory Testing for Hematologic Disorders Series
- The Big Picture: We Need to Focus On...
- LAP: A Test That Time Has Passed By
- Abbreviations
- LAP: Assay History
- LAP: Original Clinical Utility
- LAP Procedure—an Inexact Science!
- Typical Staining Type Reaction
- Subjective Nature of the Scoring Process
- LAP Scoring Example
- LAP Discontinued at Mayo Clinic
- Low LAP Scores* Not Specific for CML: A Mayo 1-Year Experience
- Low LAP Scores* Do Not Indicate Myeloid Malignancy: A Mayo 1-Year Experience
- High LAP Scores* Not Specific for PV: A Mayo 1-Year Experience
- High LAP Scores* Do Not Indicate Myeloid Malignancy: A Mayo 1-Year Experience
- LAP: A Test Whose Time Has Passed
- Consequences of an Abnormal LAP
- Alternatives to LAP
- Alternatives to LAP: BCR/ABL
- Alternatives to LAP: JAK2
- Conclusions
- Questions?
External
link
PDF
document
Excel
document
Word
document