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Leukocyte Alkaline Phosphatase Stain (LAP)

Optimizing Laboratory Testing for Hematologic
Disorders Series

Consequences of an Abnormal LAP

Slide 18

September 2010

The outcome of an abnormal LAP score is certainly not inconsequential. It may lead to a bone marrow procedure as well as cytogenetic studies, FISH and RT-PCR studies for BCR/ABL , as well as JAK2 V617F mutation analysis. All in all, an abnormal LAP may result in a series of procedures and assays that may not be needed or it will have simply delayed appropriate test selection at the initial evaluation.

Consequences of an Abnormal LAP


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