Leukocyte Alkaline Phosphatase Stain (LAP)
Optimizing Laboratory Testing for Hematologic
Disorders Series
LAP: A Test Whose Time Has Passed
September 2010
To summarize why are we discontinuing the LAP: First of all, a low LAP score is not specific for CML and can be found in patients with MPN, MDS, and even benign or reactive conditions. A high LAP score is not specific for PV and can be identified in patients with other MPNs, MDS, and numerous, benign, non-infectious conditions. Likewise, a high LAP score is not sensitive for PV as not all PV cases will have a high LAP score.
A Test Whose Time Has Passed |
Jump to section:
- Introduction
- Optimizing Laboratory Testing for Hematologic Disorders Series
- The Big Picture: We Need to Focus On...
- LAP: A Test That Time Has Passed By
- Abbreviations
- LAP: Assay History
- LAP: Original Clinical Utility
- LAP Procedure—an Inexact Science!
- Typical Staining Type Reaction
- Subjective Nature of the Scoring Process
- LAP Scoring Example
- LAP Discontinued at Mayo Clinic
- Low LAP Scores* Not Specific for CML: A Mayo 1-Year Experience
- Low LAP Scores* Do Not Indicate Myeloid Malignancy: A Mayo 1-Year Experience
- High LAP Scores* Not Specific for PV: A Mayo 1-Year Experience
- High LAP Scores* Do Not Indicate Myeloid Malignancy: A Mayo 1-Year Experience
- LAP: A Test Whose Time Has Passed
- Consequences of an Abnormal LAP
- Alternatives to LAP
- Alternatives to LAP: BCR/ABL
- Alternatives to LAP: JAK2
- Conclusions
- Questions?
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