Leukocyte Alkaline Phosphatase Stain (LAP)
Optimizing Laboratory Testing for Hematologic
Disorders Series
Low LAP Scores* Not Specific for CML: A Mayo 1-Year Experience
September 2010
The next four slides summarize a one-year experience that we had here looking at outcomes in patients who had LAPs ordered on Mayo Clinic patients. If we look at patients who had low LAP scores, there were a variety of myeloid malignancies that were associated with a low LAP. This included six cases of CML but a variety of MPN and MDS disorders were also identified with low LAP scores. This clearly points out the lack of specificity of a low LAP score for CML.
Low Scores* Not Specific for CML |
Jump to section:
- Introduction
- Optimizing Laboratory Testing for Hematologic Disorders Series
- The Big Picture: We Need to Focus On...
- LAP: A Test That Time Has Passed By
- Abbreviations
- LAP: Assay History
- LAP: Original Clinical Utility
- LAP Procedure—an Inexact Science!
- Typical Staining Type Reaction
- Subjective Nature of the Scoring Process
- LAP Scoring Example
- LAP Discontinued at Mayo Clinic
- Low LAP Scores* Not Specific for CML: A Mayo 1-Year Experience
- Low LAP Scores* Do Not Indicate Myeloid Malignancy: A Mayo 1-Year Experience
- High LAP Scores* Not Specific for PV: A Mayo 1-Year Experience
- High LAP Scores* Do Not Indicate Myeloid Malignancy: A Mayo 1-Year Experience
- LAP: A Test Whose Time Has Passed
- Consequences of an Abnormal LAP
- Alternatives to LAP
- Alternatives to LAP: BCR/ABL
- Alternatives to LAP: JAK2
- Conclusions
- Questions?
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