Helicobacter pylori: Overview and Considerations for Diagnostic Testing

Pathogenesis

August 2010

As first demonstrated by Dr. Marshall’s work, exposure to an infectious dose of Helicobacter pylori can result in an acute gastritis, with abdominal pain, nausea, and vomiting within 2 weeks of exposure.This can progress to chronic gastritis, with concomitant duodenal inflammation and development of gastric ulcers. Persistent inflammation due to Helicobacter pylori infection is considered a risk factor for eventual development of gastric adenocarcinoma.

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Pathogenesis

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Jump to section:

• Introduction
• Overview
• Helicobacter pylori
• Helicobacter spp. History¹
• Epidemiology²
• Pathogenesis
• Diagnosis of Infection
• Testing
• Types of Testing
• Endoscopy
• Rapid Urease Test
• Culture
• Types of Testing
• Urea Breath Test
• Urea Breath Test Limitations
• Serology - IgM and IgA ELISA³
• Serology: IgG ELFA
• Serology
• Serology Limitations
• Fecal Antigen Test EIA
• "Test of Cure"
• Algorithm
• Conclusions
• Tests Available From Mayo Medical Laboratories
• References
• Questions?