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Helicobacter pylori: Overview and Considerations for Diagnostic Testing


Slide 22

August 2010

Here is an algorithm located at the link indicated on the slide that summarizes the types and best usage of tests for detection of Helicobacter pylori that we have discussed today.

Please note:

  • Histology with special staining for Helicobacter pylori organisms, combined with the urea breath test, stool antigen and/or culture are the gold standard tests for diagnosis with associated high sensitivity and specificity.
  • Culture is not routinely used for initial diagnosis. Culture is required for antibiotic susceptibility testing if the physician suspects antibiotic resistance in patients who have previously failed therapy.
  • Due to low specificity, confirmation of positive serology (especially IgG) by either fecal antigen testing or urea breath testing should be considered.



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