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Helicobacter pylori: Overview and Considerations for Diagnostic Testing

Fecal Antigen Test EIA

Slide 20

August 2010

We’ve discussed the urea breath test, what about the fecal antigen test?

This test utilizes an enzyme immunoassay format, with multiple monoclonal antibodies to detect Helicobacter pylori antigens. Earlier versions of this test, which used polyclonal antibodies, were not as sensitive. The use of monoclonal antibodies have improved the sensitivity of this test to >90%, both before and after treatment. The fecal antigen test is more accurate than serology in populations with a low pretest probability of Helicobacter pylori infection. This test should not be used during treatment of Helicobacter pylori infections, as sensitivity is affected by use of proton pump inhibitors, antibiotics, bismuth, or if the patient has an actively bleeding ulcer. This test does require collection of a fresh stool sample; some patients may be averse to this. The fecal antigen test can be used 4 weeks after completion of treatment to assess success. It is an alternative to the urea breath test for this purpose.

Fecal Antigen Test EIA


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