Helicobacter pylori: Overview and Considerations for Diagnostic Testing

Overview

August 2010

Today, we will discuss the history of Helicobacter pylori, some unique characteristics of the organism and its role in pathogenesis in human disease.

In addition, I would like to discuss a variety of tests available in the clinical laboratory, and finish with current recommendations as to how these tests can best be applied for initial diagnosis and monitoring of patients during and after treatment of Helicobacter pylori infection.

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Jump to section:

• Introduction
• Overview
• Helicobacter pylori
• Helicobacter spp. History¹
• Epidemiology²
• Pathogenesis
• Diagnosis of Infection
• Testing
• Types of Testing
• Endoscopy
• Rapid Urease Test
• Culture
• Types of Testing
• Urea Breath Test
• Urea Breath Test Limitations
• Serology - IgM and IgA ELISA³
• Serology: IgG ELFA
• Serology
• Serology Limitations
• Fecal Antigen Test EIA
• "Test of Cure"
• Algorithm
• Conclusions
• Tests Available From Mayo Medical Laboratories
• References
• Questions?