Helicobacter pylori: Overview and Considerations for Diagnostic Testing

Serology: IgG ELFA

August 2010

Of all the serological tests, the enzyme linked fluorescence assay (ELFA) for IgG has the best overall sensitivity and specificity. Detection of IgG is most useful for screening symptomatic individuals for Helicobacter pylori infection, as compared to IgM and IgA. IgG detection can be performed concurrently with proton pump inhibitor treatment. Serum samples are relatively easy to obtain. However, since IgG levels may remain positive for up to a year, this test cannot be used for detection of eradication of Helicobacter pylori infection.

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Serology: IgG ELFA

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• Introduction
• Overview
• Helicobacter pylori
• Helicobacter spp. History¹
• Epidemiology²
• Pathogenesis
• Diagnosis of Infection
• Testing
• Types of Testing
• Endoscopy
• Rapid Urease Test
• Culture
• Types of Testing
• Urea Breath Test
• Urea Breath Test Limitations
• Serology - IgM and IgA ELISA³
• Serology: IgG ELFA
• Serology
• Serology Limitations
• Fecal Antigen Test EIA
• "Test of Cure"
• Algorithm
• Conclusions
• Tests Available From Mayo Medical Laboratories
• References
• Questions?