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Helicobacter pylori: Overview and Considerations for Diagnostic Testing

Rapid Urease Test

Slide 11

August 2010

The rapid urease test, also known as the CLO test, is based on a biopsy sample placed on either a reaction strip or agar gel containing urea, a buffer, and a pH indicator. The urease activity expressed by Helicobacter pylori will cause a change in the color of the pH indicator in the case of a positive test. This is a rapid test, relatively inexpensive, and sensitive in correctly selected patients. Results can be interpreted within 3 hours, although the CLO test may be held up to 24 hours.

Proton pump inhibitors, antibiotics, and bismuth will affect the result of this test, resulting in false-negatives. The rapid urease test is not recommended for patients who are currently receiving therapy for Helicobacter pylori infection.

Rapid Urease Test


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