Helicobacter pylori: Overview and Considerations for Diagnostic Testing

Rapid Urease Test

August 2010

The rapid urease test, also known as the CLO test, is based on a biopsy sample placed on either a reaction strip or agar gel containing urea, a buffer, and a pH indicator. The urease activity expressed by Helicobacter pylori will cause a change in the color of the pH indicator in the case of a positive test. This is a rapid test, relatively inexpensive, and sensitive in correctly selected patients. Results can be interpreted within 3 hours, although the CLO test may be held up to 24 hours.

Proton pump inhibitors, antibiotics, and bismuth will affect the result of this test, resulting in false-negatives. The rapid urease test is not recommended for patients who are currently receiving therapy for Helicobacter pylori infection.

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Rapid Urease Test

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• Introduction
• Overview
• Helicobacter pylori
• Helicobacter spp. History¹
• Epidemiology²
• Pathogenesis
• Diagnosis of Infection
• Testing
• Types of Testing
• Endoscopy
• Rapid Urease Test
• Culture
• Types of Testing
• Urea Breath Test
• Urea Breath Test Limitations
• Serology - IgM and IgA ELISA³
• Serology: IgG ELFA
• Serology
• Serology Limitations
• Fecal Antigen Test EIA
• "Test of Cure"
• Algorithm
• Conclusions
• Tests Available From Mayo Medical Laboratories
• References
• Questions?