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Laboratory Diagnosis of Tick-Borne Infections

Part 2



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Phylogenetic Tree

Slide 42

July 2010

This prompted us to perform some additional testing including sequencing of the amplified DNA from this sample and then compare it to sequences of other closely related organisms which allowed us to produce this phylogenetic tree showing that the organism is a novel ehrlichiosis agent that is most closely related to Ehrlichia muris, a mouse pathogen. We aretherefore calling this an Ehrlichia muris-like organism or EML. And this organism has never previously been identified from humans in North America. You can see that it is distinct from other causes of human ehrlichiosis and anaplasmosis, including Ehrlichia chaffeensis, Ehrlichia ewingii, and Anaplasma phagocytophilum. So this was an unexpected and very interesting discovery.

Phylogenetic Tree

 


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