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Laboratory Diagnosis of Tick-Borne Infections

Part 2



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PCR for Detection of Borrelia burgdorferi DNA in Blood

Slide 30

July 2010

This would support what other authors have found regarding testing of blood by PCR for Lyme disease. In general, testing of this sample type provides low clinical sensitivity, ranging from 10% to 52%. Positive results seem to correlate most with the presence of signs and symptoms of disseminated disease. And because of the low sensitivity, the CDC actually cautions against performing PCR on blood and urine for Borrellia burgdorferi DNA, and it considers them to be inappropriate specimens. Unfortunately, this isn’t widely appreciated, and many physicians continue to order Lyme PCR on blood in lieu of other more appropriate specimens or recommended serologic tests.

PCR for Detection of Borrelia burgdorferi DNA in Blood

 


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