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Laboratory Diagnosis of Tick-Borne Infections

Part 2


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Potential Roles for PCR

Slide 28

July 2010

This case nicely demonstrates some potential roles for PCR in the diagnosis of Lyme disease; specifically that it may facilitate diagnosis of early infection before a serologic response is detectable. It’s also useful for confirmation of active disease in a previously infected patient who has a positive serology, and this is actually quite important in endemic areas because it is not uncommon for individuals to have a detectable serologic response due to previous disease which may have even been asymptomatic, whereas Borrelia burgdorferi DNA would only be detected in active infection. PCR can also be useful for diagnosis of an atypical rash when tissue from a skin biopsy of the rash is tested. And it can be used for confirmation of neuroborreliosis (especially early disease), and Lyme arthritis. In fact, many different types of specimens can be tested for Lyme PCR.

Potential Roles for PCR


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