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Laboratory Diagnosis of Tick-Borne Infections

Part 1


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Conventional Methods for Diagnosis of Ehrlichiosis and Anaplasmosis

Slide 7

July 2010

This brings us to serology, which is the most commonly used conventional method for the diagnosis of ehrlichia and anaplasma infections. This technique shows high sensitivity for the diagnosis of HME or HGA by demonstrating seroconversion or a 4-fold increase in titers between acute and convalescent phase sera. Serology for these infections is most commonly performed by indirect immunofluorescence antibody, or IFA. IFA is often considered the gold-standard serologic method, but it is labor intensive and requires highly trained personnel to perform testing and interpret the results. In addition, it is subjective and therefore prone to inter-reader and inter-laboratory variability.

Conventional Methods for Diagnosis


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