Laboratory Diagnosis of Tick-Borne Infections

Lyme Disease - Serologic Assays

July 2010

Lyme Western blot assays test for IgM and IgG-class antibodies to Borrelia burgdorferi.

Western blot should be considered a supplementary serologic approach, and not confirmatory, due to the potential for false positives and inter- and intra-laboratory result variability with this method. And as we’ve discussed, the results of Western blot should be interpreted according to the current CDC criteria, and testing by Western blot is not recommended in those patients testing negative by screen EIA.

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Lyme Disease - Serologic Assays

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Jump to section:

• Introduction
• Outline
• Patient Case 1
• Laboratory Workup
• Conventional Methods for Diagnosis of Ehrlichiosis and Anaplasmosis
• Conventional Methods for Diagnosis of Ehrlichiosis and Anaplasmosis
• Conventional Methods for Diagnosis of Ehrlichiosis and Anaplasmosis
• Typical Positive Result by IFA
• Conventional Methods for Diagnosis of Ehrlichiosis and Anaplasmosis
• Diagnostic Tests for HME and HGA
• Conventional Methods for Diagnosis of Ehrlichiosis and Anaplasmosis
• Conventional Methods for Diagnosis of Ehrlichiosis and Anaplasmosis
• Patient Case 2
• Giemsa-stained Preparation Slide
• Giemsa-stained Preparation Slide
• Conventional Methods for Diagnosis of Babesia
• Conventional Methods for Diagnosis of Babesia
• Conventional Methods for Diagnosis of Babesia
• Conventional Methods for Diagnosis of Babesia
• Conventional Methods for Diagnosis of Babesia
• Patient Case 3
• Lyme Disease - Diagnostic Approach
• Conventional Methods for Diagnosis of Lyme Disease
• Patient Case 3 (continued)
• Diagnosis of Lyme Disease
• Lyme Disease - Serologic Assays
• Lyme Disease - Serologic Assays
• Lyme Disease - Serologic Assays
• Patient Case 3 (continued)
• Lyme Disease - Serologic Assays
• Patient Case 3 (continued)
• Lyme Disease - Factors to Consider
• Conclusions
• References
• Questions?