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Laboratory Diagnosis of Tick-Borne Infections

Part 1


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Lyme Disease - Serologic Assays

Slide 26

July 2010

Regarding the screen enzyme immunoassay, the sensitivity of the assay may vary with the disease stage. As we can see in this table, the sensitivity of the screening EIA in stage 1 of the disease may be as low as 70-75%. In contrast, when testing is performed during stages 2 and 3 of Lyme disease, the sensitivity increases to greater than 90%. An additional point to consider is that early administration of antibiotics may weaken or delay the antibody response, and the sensitivity of EIA may be decreased. As we’ve already reviewed, specimens testing positive or equivocal by the screening method should be tested by Western blot.

Lyme Disease - Serologic Assays


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