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Laboratory Diagnosis of Tick-Borne Infections

Part 1


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Conventional Methods for Diagnosis of Ehrlichiosis and Anaplasmosis

Slide 12

July 2010

Finally, while the specificity of Ehrlichia and Anaplasma serology is good, particularly for the IgG assays, there is the potential that cross-reactivity may occur between HME and HGA serologic tests. Because of this, testing for both may assist in the interpretation, as the etiologic agent usually shows the higher endpoint titer, for example, in cases of Anaplasmosis, we typically see that the HGA titer is greater than the HME titer, often times by at least several fold. When IgM testing is performed for HME and HGA, a positive result without an accompanying IgG titer should be interpreted with caution, as false positives can occur due to Rocky Mountain spotted fever, typhus, Q fever, Lyme disease, or EBV, or elevated rheumatoid factor.

Methods for Diagnosis


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