Laboratory Diagnosis of Tick-Borne Infections

Conventional Methods for Diagnosis of Ehrlichiosis and Anaplasmosis

July 2010

Finally, while the specificity of Ehrlichia and Anaplasma serology is good, particularly for the IgG assays, there is the potential that cross-reactivity may occur between HME and HGA serologic tests. Because of this, testing for both may assist in the interpretation, as the etiologic agent usually shows the higher endpoint titer, for example, in cases of Anaplasmosis, we typically see that the HGA titer is greater than the HME titer, often times by at least several fold. When IgM testing is performed for HME and HGA, a positive result without an accompanying IgG titer should be interpreted with caution, as false positives can occur due to Rocky Mountain spotted fever, typhus, Q fever, Lyme disease, or EBV, or elevated rheumatoid factor.

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Jump to section:

• Introduction
• Outline
• Patient Case 1
• Laboratory Workup
• Conventional Methods for Diagnosis of Ehrlichiosis and Anaplasmosis
• Conventional Methods for Diagnosis of Ehrlichiosis and Anaplasmosis
• Conventional Methods for Diagnosis of Ehrlichiosis and Anaplasmosis
• Typical Positive Result by IFA
• Conventional Methods for Diagnosis of Ehrlichiosis and Anaplasmosis
• Diagnostic Tests for HME and HGA
• Conventional Methods for Diagnosis of Ehrlichiosis and Anaplasmosis
• Conventional Methods for Diagnosis of Ehrlichiosis and Anaplasmosis
• Patient Case 2
• Giemsa-stained Preparation Slide
• Giemsa-stained Preparation Slide
• Conventional Methods for Diagnosis of Babesia
• Conventional Methods for Diagnosis of Babesia
• Conventional Methods for Diagnosis of Babesia
• Conventional Methods for Diagnosis of Babesia
• Conventional Methods for Diagnosis of Babesia
• Patient Case 3
• Lyme Disease - Diagnostic Approach
• Conventional Methods for Diagnosis of Lyme Disease
• Patient Case 3 (continued)
• Diagnosis of Lyme Disease
• Lyme Disease - Serologic Assays
• Lyme Disease - Serologic Assays
• Lyme Disease - Serologic Assays
• Patient Case 3 (continued)
• Lyme Disease - Serologic Assays
• Patient Case 3 (continued)
• Lyme Disease - Factors to Consider
• Conclusions
• References
• Questions?