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Laboratory Diagnosis of Tick-Borne Infections

Part 1


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Conventional Methods for Diagnosis of Ehrlichiosis and Anaplasmosis

Slide 11

July 2010

Other important factors to consider when ordering and interpreting serology results for Ehrlichia and Anaplasma include the fact that IgG may persist for months to years in exposed patients, and that there may be a high seroprevalence in endemic areas. Because of this, IgG-class antibodies to HME or HGA may be detected in individuals with no clinical evidence of acute infection. Additionally, an analysis of a single, acute-phase serum sample has low sensitivity, and the sensitivity increases significantly when testing is performed on both acute and convalescent phase sera, preferably collected at least 2 weeks apart.

Methods for Diagnosis


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