Laboratory Diagnosis of Tick-Borne Infections

Diagnostic Tests for HME and HGA

July 2010

One of the most important factors to consider when interpreting the results of serology in cases of suspected HME or HGA is the time-interval between the onset of clinical illness and when the serum sample is collected for testing. This relationship is shown in the table on this slide, in which we can see that the sensitivity of serology for HME and HGA is very poor, between 20 and 50%, when the specimen is collected during the first week after symptom onset. However, the sensitivity of serology increases significantly during week 2 post onset, and by the third week, serology is positive in greater than 90% of cases of HME and HGA.

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Diagnostic Tests for HME and HGA

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• Introduction
• Outline
• Patient Case 1
• Laboratory Workup
• Conventional Methods for Diagnosis of Ehrlichiosis and Anaplasmosis
• Conventional Methods for Diagnosis of Ehrlichiosis and Anaplasmosis
• Conventional Methods for Diagnosis of Ehrlichiosis and Anaplasmosis
• Typical Positive Result by IFA
• Conventional Methods for Diagnosis of Ehrlichiosis and Anaplasmosis
• Diagnostic Tests for HME and HGA
• Conventional Methods for Diagnosis of Ehrlichiosis and Anaplasmosis
• Conventional Methods for Diagnosis of Ehrlichiosis and Anaplasmosis
• Patient Case 2
• Giemsa-stained Preparation Slide
• Giemsa-stained Preparation Slide
• Conventional Methods for Diagnosis of Babesia
• Conventional Methods for Diagnosis of Babesia
• Conventional Methods for Diagnosis of Babesia
• Conventional Methods for Diagnosis of Babesia
• Conventional Methods for Diagnosis of Babesia
• Patient Case 3
• Lyme Disease - Diagnostic Approach
• Conventional Methods for Diagnosis of Lyme Disease
• Patient Case 3 (continued)
• Diagnosis of Lyme Disease
• Lyme Disease - Serologic Assays
• Lyme Disease - Serologic Assays
• Lyme Disease - Serologic Assays
• Patient Case 3 (continued)
• Lyme Disease - Serologic Assays
• Patient Case 3 (continued)
• Lyme Disease - Factors to Consider
• Conclusions
• References
• Questions?