Platelet Esoteric Testing
A Case Study
Ultrastructure Studies Whole Mount
June 2010
The best way to study platelet storage pool is platelet electron microscopy. The first method is the whole mount EM. Patient’s platelet rich plasma was applied directly onto the EM grid and examined. The dense bodies contain calcium which blocks electron beam and consequently creates an ink dot shadow. By counting these ink dots we can estimate dense body count per platelet. The normal range is more than 2 dense bodies per platelets. And this case, the mean dense body count is 10 per platelet, so there is no evidence of dense body deficiency.
Ultrastructure Studies Whole Mount |
Jump to section:
- Introduction
- Bleeding and Thrombosing Diseases: 2010 Mayo Update
- Clinical Presentation
- Bleeding History - 1
- Bleeding History - 2
- Complete Blood Count (CBC)
- Peripheral Blood Smear
- Coagulation Studies
- Platelet Function Studies
- Differential Diagnosis ?
- Laboratory Approach to Qualitative Platelet Disorders
- Platelet Qualitative Disorders
- Laboratory Systemic Approach
- Macro-thrombocytopenia
- Flow Cytometry Studies
- Platelet Activity By Flow Cytometry
- Macro-thrombocytopenia
- Ultrastructure Studies Whole Mount
- Ultrastructure Studies Thin Sections
- Macro-thrombocytopenia
- Molecular Studies
- Final Diagnosis
- Global Prevalence of GPS
- GPS-Clinical Presentation
- Laboratory Findings
- Differential Diagnoses of Gray Platelets
- Unique Bone Marrow Findings in Patients with GPS
- Clinical Presentation
- Myelofibrosis
- Emperipolesis
- GPS-Treatment
- Summary
- Acknowledgment
- Bleeding and Thrombosing Diseases: 2010 Mayo Update
- Questions?
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