Platelet Esoteric Testing
A Case Study
Flow Cytometry Studies
June 2010
We first look at the possibility of a surface deficiency. Platelet flow cytometry study is the gold stand test for platelet surface deficiency. In this case, the patient had no deficiency of glycoprotein IIb IIIa, Ib-V-IX or collagen receptor deficiency. When platelets are activated by either thrombin analog sTRAP or ADP, platelets had normal glycoprotein IIb IIIa response, but slightly decreased surface P-selectin expression.
Flow Cytometry Studies |
Jump to section:
- Introduction
- Bleeding and Thrombosing Diseases: 2010 Mayo Update
- Clinical Presentation
- Bleeding History - 1
- Bleeding History - 2
- Complete Blood Count (CBC)
- Peripheral Blood Smear
- Coagulation Studies
- Platelet Function Studies
- Differential Diagnosis ?
- Laboratory Approach to Qualitative Platelet Disorders
- Platelet Qualitative Disorders
- Laboratory Systemic Approach
- Macro-thrombocytopenia
- Flow Cytometry Studies
- Platelet Activity By Flow Cytometry
- Macro-thrombocytopenia
- Ultrastructure Studies Whole Mount
- Ultrastructure Studies Thin Sections
- Macro-thrombocytopenia
- Molecular Studies
- Final Diagnosis
- Global Prevalence of GPS
- GPS-Clinical Presentation
- Laboratory Findings
- Differential Diagnoses of Gray Platelets
- Unique Bone Marrow Findings in Patients with GPS
- Clinical Presentation
- Myelofibrosis
- Emperipolesis
- GPS-Treatment
- Summary
- Acknowledgment
- Bleeding and Thrombosing Diseases: 2010 Mayo Update
- Questions?
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