Platelet Esoteric Testing
A Case Study
Differential Diagnosis ?
June 2010
Based on these laboratory results, here are some potential differential diagnoses:
1. Her bleeding is most likely caused by thrombocytopenia, a quantitative platelet deficiency, since there is no evidence of a qualitative platelet disorder. 2. Qualitative platelet dysfunction present (detected by prolonged PFA100-Epinephrine closure time). 3. Patient most likely has persistent ITP. 4. In light of patient’s significant bleeding history and abnormal peripheral blood findings, further platelet testing is indicated. We favored number 4, therefore we further pursued additional testing.
Differential Diagnosis ? |
Jump to section:
- Introduction
- Bleeding and Thrombosing Diseases: 2010 Mayo Update
- Clinical Presentation
- Bleeding History - 1
- Bleeding History - 2
- Complete Blood Count (CBC)
- Peripheral Blood Smear
- Coagulation Studies
- Platelet Function Studies
- Differential Diagnosis ?
- Laboratory Approach to Qualitative Platelet Disorders
- Platelet Qualitative Disorders
- Laboratory Systemic Approach
- Macro-thrombocytopenia
- Flow Cytometry Studies
- Platelet Activity By Flow Cytometry
- Macro-thrombocytopenia
- Ultrastructure Studies Whole Mount
- Ultrastructure Studies Thin Sections
- Macro-thrombocytopenia
- Molecular Studies
- Final Diagnosis
- Global Prevalence of GPS
- GPS-Clinical Presentation
- Laboratory Findings
- Differential Diagnoses of Gray Platelets
- Unique Bone Marrow Findings in Patients with GPS
- Clinical Presentation
- Myelofibrosis
- Emperipolesis
- GPS-Treatment
- Summary
- Acknowledgment
- Bleeding and Thrombosing Diseases: 2010 Mayo Update
- Questions?
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