Diagnostic Testing Algorithms for Celiac Disease

Diagnosis of Celiac Disease

updated June 2011

The diagnosis of celiac disease relies significantly on laboratory and biopsy evaluation.

A presumptive diagnosis can be established if a patient has positive serology, which I will expand on in a moment, and an intestinal biopsy that demonstrates villous atrophy.  Once a presumptive diagnosis has been established, the patient will be started on a gluten-free diet.  The goal of this treatment is to remove the initiating source of the inflammatory response.  Once gluten has been successfully abolished from the diet, the patient should begin to see resolution of their clinical symptoms, which is often accompanied by conversion to a negative serology and reconstitution of the villae in the small intestine.  Using these criteria, a definitive diagnosis of celiac disease can be established.

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Diagnosis of Celiac Disease

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Jump to section:

• Introduction
• Introduction to Celiac Disease
• Clinical Features of Celiac Disease
• Development of Celiac Disease
• Diagnosis of Celiac Disease
• Diagnosis of Celiac Disease
• HLA Typing For Celiac Disease
• Diagnosis of Celiac Disease
• Algorithm
• Algorithm
• Summary
• Laboratory Algorithms
• Algorithm Breakdown
• Algorithm Breakdown
• Algorithm Breakdown
• Summary
• Questions?