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Diagnostic Testing Algorithms for Celiac Disease


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Introduction to Celiac Disease

Slide 2

updated June 2011

Celiac disease is a chronic inflammatory condition that primarily affects the small intestine.

It is caused by an inflammatory response mounted by the patient’s own immune system against dietary gluten.

This inflammatory response ultimately results in damage and atrophy of the villae within the small intestine.  In the upper figure, you see a biopsy of a normal small intestine, with intact villae.  In the bottom 2 figures, you see the partial and total villous atrophy that occurs in celiac disease as a result of the inflammatory response.

Introduction to Celiac Disease


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