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Cerebrospinal Fluid Bacterial Antigen

No Benefit Beyond Gram Stain


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Slide 9

May 2010

In an effort to increase the sensitivity of cerebrospinal fluid Gram stain, a cytocentrifugation procedure was implemented in January of 2007. All 5 specimens with classic bacterial meningitis pathogens present in which the Gram stain was negative (including those in which the bacterial antigen test was positive) were performed prior to the implementation of the cytocentrifugation procedure. Had they been performed using the more sensitive cytocentrifugation protocol, the Gram stains in these cases may have been positive.



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