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Understanding Viral Load Assays for Cytomegalovirus and Epstein-Barr Virus


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EBV and Posttransplantation Lymphoproliferative Disorder

Slide 7

March 2010

Transplant patients with EBV infections are at risk for post-transplantation lymphoproliferative disorder, or PTLD, which can manifest anywhere along a spectrum of disease from mononucleosis-like symptoms to lymphoma.

PTLDs are caused by an abnormal proliferation of EBV-infected B cells, which result from the lack of adequate T-cell function that usually keep B-cell replication under control. Treatments or conditions that reduce T-cell function in the patient increase the risk for PTLD.

Although the mortality can be quite high, the incidence of PTLD is fairly low, and depends on factors such as the organ transplanted, age and seropositivity of the patient, and the type of immunosuppressive regimen.



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