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Understanding Viral Load Assays for Cytomegalovirus and Epstein-Barr Virus



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When to Treat CMV?

Slide 5

March 2010

The decision to treat CMV must be informed by a number of factors: The patient and transplant type, the laboratory method used to quantify the viral load, as well as the specimen submitted to the laboratory.

In the literature, there are many proposed decision points for treatment of CMV, anywhere from 200 (or 2.3 log) copies per milliliter to 86,000 (or 4.9 log) copies per milliliter. The range of values is dependent not only on differences in the patient population, but also in the different methodologies used to determine the viral loads

One approach is to stratify patients by risk type. In this model, high-risk patients should have the lowest threshold, or tolerance before treatment, whereas moderate or lower-risk patients may not require treatment unless the viral load passes a higher threshold. Please note that these numbers are examples, and may not apply to your local testing methodology.

When to Treat CMV?

 


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