Cervical Cytology and HPV Testing

High-Risk HPV Testing⁵

March 2010

So, when should you use high-risk HPV testing as part of the initial testing in GYN cytology? It is appropriate only in specific populations. In postmenopausal women you can use it as part of the routine screening in conjunction with regular cytology. This is an FDA approved test.

Patients with an initial cytologic diagnosis of ASC-US, HPV can be used as part of the triage. Patients with a cytologic diagnosis of low-grade squamous intraepithelial lesion (LSIL) who are postmenopausal can also be tested for HPV prior to colposcopic examination if the HPV is negative, then they are not at significant risk for developing a significant lesion and may be followed.

For women who are greater than 30 years of age, HPV again can be used as part of the routine screening in conjunction with cytology and if both cytology and HPV are negative, then these individuals should not be screened again for 3 years. Patients with a cytologic diagnosis of ASC-US, again HPV can be used as a triage mechanism to determine which ones need to go on to colposcopic examination. For women between the ages of 20 and 30, HPV should only be used as triage for ASC-US.

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High-Risk HPV Testing

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Jump to section:

• Introduction
• Anogenital HPV Types¹
• Mechanism for Transformation
• Natural History of HPV Infections²
• HPV DNA Testing in Cervical Specimens: Uses
• Meta-analysis of ASCUS-HPV Triage Studies³
• 2006 Consensus Guidelines-ASC-US
• 2006 Consensus Guidelines-ASC-US
• 2006 ASCCP Guidelines and CETC Recommendations
• 2006 Consensus Guidelines for ASC-US: Special Circumstances
• High-Risk HPV Testing⁵
• Low-Risk HPV Testing
• References
• Questions?