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Kidney Stones

Update in Diagnosis and Management

Control of Urinary Citrate: Largely Due to Systemic Acid Base Balance

Slide 19

February 2010

Urinary citrate levels are largely determined at the level of the proximal tubule. Filtered citrate can be reabsorbed there, enter the citric acid cycle, and be broken down to generate bicarbonate ions. Control of these events is driven largely by systemic acid base status, which in turn affects intracellular pH. This makes sense, since the net result is to regenerate bicarbonate and help correct the acidosis.

Control of Citrate


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