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Kidney Stones

Update in Diagnosis and Management


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What is Oxalate?

Slide 15

February 2010

Increased urinary oxalate is another important risk factor for calcium oxalate stones. Oxalate is a small molecule composed of 2 carbons and 4 oxygens. Since humans have no enzyme to degrade oxalate, it must be eliminated by the urinary or GI tract. The major issue in the urine is that oxalate likes to bind calcium, and calcium oxalate is fairly insoluble. And these calcium oxalate crystals can grow into stones. Certain plants are high in oxalate, such as rhubarb, spinach, and nuts. However, a larger percentage of dietary oxalate comes from foods that are more moderate in oxalate content but eaten in greater amounts, such as potatoes.

What is Oxalate?


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