Chronic Granulomatous Disease (CGD)

Introduction

January 2010

Welcome to Mayo Medical Laboratories' Hot Topics. These presentations provide short discussion of current topics and may be helpful to you in your practice.

Our presenters for this program are Dr. Avni Joshi and Dr. Roshini Abraham. During this program, we will be discussing general concepts of primary immunodeficiencies and their incidence before moving into details on the pathogenesis, common clinical features and treatment, and laboratory evaluation for Chronic Granulomatous Disease (CGD).

Before we begin our discussion on CGD, we will provide an introductory overview on primary immunodeficiencies and the immune system.

Introduction

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Jump to section:

• Primary Immunodeficiencies (PIDs): What Are They?
• Primary Immunodeficiencies (PIDs): What Are They?
• Relative Distribution of the PIDs
• Components and Kinetics of the Immune Response
• Mechanisms of Innate Immunity
• Defect in the Innate Immune System: Chronic Granulomatous Disease
• Molecular Pathogenesis
• Clinical Features
• Laboratory Diagnosis of Neutrophil Oxidative Burst
• Nitro Blue-Tetrazolium Test (NBT)
• Dihydrorhodamine (DHR) Flow Cytometric Assay for Diagnosis of CGD
• Neutrophil Oxidative Burst: Normal Individual
• X-linked CGD
• Symptomatic Female Carrier with CGD
• Autosomal Recessive CGD
• Autosomal Recessive CGD
• Laboratory Test Ordering Information
• Questions?