Chronic Granulomatous Disease (CGD)

Mechanisms of Innate Immunity

January 2010

As discussed in the previous slide, the phagocytes and complement are integral components of the innate immune response. The phagocytes can be subdivided into 2 groups - macrophages and monocytes, and neutrophils. Neutrophils typically can be considered the "first responders or EMTs" of the innate immune compartment. However, in submucosal tissue macrophages are the first to encounter pathogens and are later reinforced by neutrophils. Again as mentioned in the previous slide, both macrophages and neutrophils recognize pathogens by means of cell-surface receptors that can distinguish between surface molecules displayed by the host and the pathogen.

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Jump to section:

• Introduction
• Primary Immunodeficiencies (PIDs): What Are They?
• Primary Immunodeficiencies (PIDs): What Are They?
• Relative Distribution of the PIDs
• Components and Kinetics of the Immune Response
• Mechanisms of Innate Immunity
• Defect in the Innate Immune System: Chronic Granulomatous Disease
• Molecular Pathogenesis
• Clinical Features
• Laboratory Diagnosis of Neutrophil Oxidative Burst
• Nitro Blue-Tetrazolium Test (NBT)
• Dihydrorhodamine (DHR) Flow Cytometric Assay for Diagnosis of CGD
• Neutrophil Oxidative Burst: Normal Individual
• X-linked CGD
• Symptomatic Female Carrier with CGD
• Autosomal Recessive CGD
• Autosomal Recessive CGD
• Laboratory Test Ordering Information
• Questions?