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Chronic Granulomatous Disease (CGD)

Clinical Features and Laboratory Testing



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Components and Kinetics of the Immune Response

Slide 5

January 2010

This is a graphical representation or cartoon of both the components and the kinetics of the immune response. The innate immune compartment, which includes neutrophils, monocytes, macrophages, dendritic cells, complement and even NK cells, is generally activated within a few minutes to hours after encounter with a pathogen and is typically antigen non-specific. Pathogen recognition includes the PAMPs - pathogen-associated molecular patterns. On the other hand, the adaptive immune response, which includes B cells, T cells and again NK cells (which can play a dual role in both compartments of immunity) is antigen-specific and requires more time for activation and typically takes 96 hours or greater. However, the antigen-specificity gives it greater "potency" in combating pathogenic targets.

Components and Kinetics

 


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