Chronic Granulomatous Disease (CGD)

Components and Kinetics of the Immune Response

January 2010

This is a graphical representation or cartoon of both the components and the kinetics of the immune response. The innate immune compartment, which includes neutrophils, monocytes, macrophages, dendritic cells, complement and even NK cells, is generally activated within a few minutes to hours after encounter with a pathogen and is typically antigen non-specific. Pathogen recognition includes the PAMPs - pathogen-associated molecular patterns. On the other hand, the adaptive immune response, which includes B cells, T cells and again NK cells (which can play a dual role in both compartments of immunity) is antigen-specific and requires more time for activation and typically takes 96 hours or greater. However, the antigen-specificity gives it greater "potency" in combating pathogenic targets.

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Jump to section:

• Introduction
• Primary Immunodeficiencies (PIDs): What Are They?
• Primary Immunodeficiencies (PIDs): What Are They?
• Relative Distribution of the PIDs
• Components and Kinetics of the Immune Response
• Mechanisms of Innate Immunity
• Defect in the Innate Immune System: Chronic Granulomatous Disease
• Molecular Pathogenesis
• Clinical Features
• Laboratory Diagnosis of Neutrophil Oxidative Burst
• Nitro Blue-Tetrazolium Test (NBT)
• Dihydrorhodamine (DHR) Flow Cytometric Assay for Diagnosis of CGD
• Neutrophil Oxidative Burst: Normal Individual
• X-linked CGD
• Symptomatic Female Carrier with CGD
• Autosomal Recessive CGD
• Autosomal Recessive CGD
• Laboratory Test Ordering Information
• Questions?