Chronic Granulomatous Disease (CGD)

Relative Distribution of the PIDs

January 2010

The PIDs can be classified based on the component of the immune system that are affected - these include humoral or B cell defects, T cell or cellular defects, phagocytic defects and complement defects. The humoral or antibody deficiencies account for the majority of the PIDs, ~65%, while "pure" cellular deficiencies account for only 5% of the total cases of PIDs. The combined cellular and humoral immune deficiencies account for another 15%, while the phagocytic and complement deficiencies account for the remaining 10% and 5% respectively.

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Jump to section:

• Introduction
• Primary Immunodeficiencies (PIDs): What Are They?
• Primary Immunodeficiencies (PIDs): What Are They?
• Relative Distribution of the PIDs
• Components and Kinetics of the Immune Response
• Mechanisms of Innate Immunity
• Defect in the Innate Immune System: Chronic Granulomatous Disease
• Molecular Pathogenesis
• Clinical Features
• Laboratory Diagnosis of Neutrophil Oxidative Burst
• Nitro Blue-Tetrazolium Test (NBT)
• Dihydrorhodamine (DHR) Flow Cytometric Assay for Diagnosis of CGD
• Neutrophil Oxidative Burst: Normal Individual
• X-linked CGD
• Symptomatic Female Carrier with CGD
• Autosomal Recessive CGD
• Autosomal Recessive CGD
• Laboratory Test Ordering Information
• Questions?