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Prosthetic Joint Infection Diagnosis



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Criteria for Diagnosis of Prosthetic Joint Infection

Slide 9

January 2010

The pathogenesis of Prosthetic Joint Infection involves the formation of microbial biofilms.  Bacteria, typically inoculated at the time of implantation, adhere to the implant and enter into a phenotypically unique, biofilm state in which they are relatively protected from conventional antimicrobial agents and the host immune system.  In this biofilm state, they grow slowly and elaborate an extracellular polymeric matrix.  As mentioned, in the biofilm state, they are relatively resistant to antimicrobial agents and the host immune system.  However, the immune system is attracted to the site of infection, and this can result in destruction of tissues surrounding the prosthesis and the finding, for example, of acute inflammation in periprosthetic tissues.

Criteria for Diagnosis

 


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