Red Cell Folate Testing
Unwarranted and Overutilized in the Era of Folic Acid Supplementation
Differences Between Folate Immunoassays
November 2010
There are notable differences between results obtained for red cell and serum folate assays between manufacturers, which is not an uncommon occurrence for any unstandardized assay on the market. Bias between test methods and platforms may be as low as 10% and as high as 70%, despite similar claims of traceability, and occurs throughout the analytical range of the assays. Therefore, there is currently no one standard for folate measurement and values can vary significantly from one laboratory to the next because of method differences.
Differences Between Folate Immunoassays |
Jump to section:
- Introduction
- Folate
- Folate
- Selected Food Sources of Folate and Folic Acid*
- Causes of Folate Deficiency
- Laboratory Diagnosis of Folate Deficiency
- Folate and Vitamin B12 Deficiency
- Quantitation of Folate: Methods
- Differences Between Folate Immunoassays
- Analytical Imprecision: RBC Folate (CAP Surveys)
- Equivalence of Serum and RBC Folate
- Modern Folate Deficiency is Rare
- Mayo RBC/Serum Folate Orders 1999-2009
- Conclusions
- Questions?
External
link
PDF
document
Excel
document
Word
document