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Red Cell Folate Testing

Unwarranted and Overutilized in the Era of Folic Acid Supplementation


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Modern Folate Deficiency is Rare

Slide 12

November 2010

Results from our laboratory and other studies suggest that American populations have indeed attained adequate concentrations of folate and that modern folate deficiency has essentially been eliminated. This graph shows results from Mayo Clinic patients (in Rochester, MN only) who had serum folate ordered over the last two years. Of the 24,177 serum folates performed, only one-half of a percent were less than 3.0 ng/mL, which is the deficient concentration as defined by NHANES and the CDC. Thus, a huge majority of samples are being tested that are normal; there are not many other routine laboratory tests that have this type of distribution, normally a more Gaussian distribution of results can be observed.

Modern Folate Deficiency is Rare


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