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Red Cell Folate Testing

Unwarranted and Overutilized in the Era of Folic Acid Supplementation


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Analytical Imprecision: RBC Folate (CAP Surveys)

Slide 10

November 2010

Analytical imprecision is notably worse with red cell folate assays compared to serum folate assays. This has been well documented in the literature and noticeable in proficiency testing surveys, where the variability even within the same peer group may be up to 50%. Manual sample preparation and variability among procedures to completely lyse the red blood cells are likely responsible for much of this variation.

Analytical Imprecision: RBC Folate


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