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Analytical Issues Surrounding Troponin Assays


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2007 Universal Definition of MI1

Slide 6

October 2010

In 2007, a universal definition of MI was established to improve the accuracy of MI diagnosis. Key to this universal definition was the use of a highly sensitive and specific biomarker, troponin, determined from serial blood samples. It requires detection of a rise and/or fall of cardiac biomarkers with at least 1 of those concentrations being above the 99th percentile of the assay and evidence of myocardial ischemia (being symptoms, ECG changes, pathological Q waves, or imaging evidence). The timing of samples remains critical and serial testing is recommended for interpretation.

2007 Universal Definition of MI1


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