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Analytical Issues Surrounding Troponin Assays



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Troponin Elevations are Greater and Persist Over Longer Time Periods

Slide 5

October 2010

Cardiac troponin is a structural biomarker of cardiac necrosis and is the best marker for definitive AMI diagnosis. Troponins appear in the serum relatively early after the onset of symptoms and remain abnormal for 4-10 days. Elevations of troponin T persist longer than troponin I because it is larger (at 37 kDa versus 24 kDa). Although worth noting is an increase in troponin after unstable angina or small myocardial infarction, although in both situations the troponin concentration would be above the 99th percentile.

Troponin Elevations

 


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