Analytical Issues Surrounding Troponin Assays
Cardiac Markers
October 2010
Presently most laboratories run a troponin assay, either troponin T or troponin I, and may also offer testing for CK-MB and/or myoglobin. Troponin demonstrates improved myocardial specificity and sensitivity over both CK-MB and myoglobin and obsoletes the utility of either marker.
Cardiac Markers |
Jump to section:
- Introduction
- Challenges in Cardiovascular Medicine
- Shades of Gray
- Cardiac Markers
- Troponin Elevations are Greater and Persist Over Longer Time Periods
- 2007 Universal Definition of MI1
- Serial Sampling
- Elevation of cTn in Patients Without Overt Ischemic Heart Disease1
- Analytic Confusion: Sensitivity and Imprecision of cTn Assays
- Analytical Definitions (Related to Troponin)
- Current Troponin Assays
- Defining the 99th Percentile (Normal Population)
- Troponin T or Troponin I: Does it Matter?
- Is CK-MB Needed Anymore?
- Recommendations for Point-of-Care Cardiac Marker Testing2,3
- Does POCT Make Any Difference?
- What About the High-Sensitive Troponin Assays?
- Why All the Hype for High-Sensitivity Troponin?
- Troponin Concentrations and Diagnostic Accuracy4
- How Sensitive Does Troponin Testing Really Need to Be?
- Current Mayo Cardiac Biomarker Panel
- Current Mayo Cardiac Biomarker Panel
- Conclusions
- References
- Questions?
- Disclosure
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