Analytical Issues Surrounding Troponin Assays
Current Mayo Cardiac Biomarker Panel
October 2010
We further report a "delta" value with our panel; the delta is calculated between the 0-3 and 0-6 hour samples and is reported as significant or not significant. Analytically significant changes are defined based on the baseline troponin. If the baseline troponin is < or =0.2 ng/mL, a change of 0.03 ng/mL or greater would be considered significant. And, if the baseline troponin is greater than 0.20 ng/mL, a change of plus or minus 20% would be considered significant.
Current Mayo Cardiac Biomarker Panel |
Jump to section:
- Introduction
- Challenges in Cardiovascular Medicine
- Shades of Gray
- Cardiac Markers
- Troponin Elevations are Greater and Persist Over Longer Time Periods
- 2007 Universal Definition of MI1
- Serial Sampling
- Elevation of cTn in Patients Without Overt Ischemic Heart Disease1
- Analytic Confusion: Sensitivity and Imprecision of cTn Assays
- Analytical Definitions (Related to Troponin)
- Current Troponin Assays
- Defining the 99th Percentile (Normal Population)
- Troponin T or Troponin I: Does it Matter?
- Is CK-MB Needed Anymore?
- Recommendations for Point-of-Care Cardiac Marker Testing2,3
- Does POCT Make Any Difference?
- What About the High-Sensitive Troponin Assays?
- Why All the Hype for High-Sensitivity Troponin?
- Troponin Concentrations and Diagnostic Accuracy4
- How Sensitive Does Troponin Testing Really Need to Be?
- Current Mayo Cardiac Biomarker Panel
- Current Mayo Cardiac Biomarker Panel
- Conclusions
- References
- Questions?
- Disclosure
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