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Analytical Issues Surrounding Troponin Assays



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Troponin Concentrations and Diagnostic Accuracy4

Slide 19

October 2010

Two recent papers in the New England Journal of Medicine reported results from large, multicenter evaluations of the diagnostic performance of several sensitive assays. The 2 studies were consistent in their conclusions, with an improved accuracy in AMI diagnosis. The cardiac troponin concentrations at patient presentation, as noted in this figure, were significantly higher in patients with a final diagnosis of AMI than in those who had a different diagnosis of unstable angina or other cardiac causes but not coronary artery disease. Diagnostic performance of the assays was similar in STEMI vs non-STEMI patients.

Concentrations and Diagnostic Accuracy

 


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