Analytical Issues Surrounding Troponin Assays
Why All the Hype for High-Sensitivity Troponin?
October 2010
What is all the hype about high-sensitive troponin assays? While there are no FDA-approved high-sensitive assays, there are many in development and being used for research use only. Their use has been shown to diagnose MI earlier, greater prediction of death or future MI, and an improvement in risk stratification. It should be noted that the improvement in sensitivity is at the expense of specificity.
Why All the Hype? |
Jump to section:
- Introduction
- Challenges in Cardiovascular Medicine
- Shades of Gray
- Cardiac Markers
- Troponin Elevations are Greater and Persist Over Longer Time Periods
- 2007 Universal Definition of MI1
- Serial Sampling
- Elevation of cTn in Patients Without Overt Ischemic Heart Disease1
- Analytic Confusion: Sensitivity and Imprecision of cTn Assays
- Analytical Definitions (Related to Troponin)
- Current Troponin Assays
- Defining the 99th Percentile (Normal Population)
- Troponin T or Troponin I: Does it Matter?
- Is CK-MB Needed Anymore?
- Recommendations for Point-of-Care Cardiac Marker Testing2,3
- Does POCT Make Any Difference?
- What About the High-Sensitive Troponin Assays?
- Why All the Hype for High-Sensitivity Troponin?
- Troponin Concentrations and Diagnostic Accuracy4
- How Sensitive Does Troponin Testing Really Need to Be?
- Current Mayo Cardiac Biomarker Panel
- Current Mayo Cardiac Biomarker Panel
- Conclusions
- References
- Questions?
- Disclosure
External
link
PDF
document
Excel
document
Word
document