Analytical Issues Surrounding Troponin Assays
What About the High-Sensitive Troponin Assays?
October 2010
So, what about high-sensitive troponin assays? Remembering the definition of a high-sensitive assay being a total imprecision of less than 10% at the 99th percentile and some would propose also being able to quantitate over 50% of normal values below that 99th percentile.
High-Sensitive Troponin Assays |
Jump to section:
- Introduction
- Challenges in Cardiovascular Medicine
- Shades of Gray
- Cardiac Markers
- Troponin Elevations are Greater and Persist Over Longer Time Periods
- 2007 Universal Definition of MI1
- Serial Sampling
- Elevation of cTn in Patients Without Overt Ischemic Heart Disease1
- Analytic Confusion: Sensitivity and Imprecision of cTn Assays
- Analytical Definitions (Related to Troponin)
- Current Troponin Assays
- Defining the 99th Percentile (Normal Population)
- Troponin T or Troponin I: Does it Matter?
- Is CK-MB Needed Anymore?
- Recommendations for Point-of-Care Cardiac Marker Testing2,3
- Does POCT Make Any Difference?
- What About the High-Sensitive Troponin Assays?
- Why All the Hype for High-Sensitivity Troponin?
- Troponin Concentrations and Diagnostic Accuracy4
- How Sensitive Does Troponin Testing Really Need to Be?
- Current Mayo Cardiac Biomarker Panel
- Current Mayo Cardiac Biomarker Panel
- Conclusions
- References
- Questions?
- Disclosure
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