Diagnostic Challenges of Celiac Disease

Comparison of Serological Tests

June 2010

So in summary, human tissue transglutaminase ELISA testing, especially for the IgA isotype, is probably the single best test for accuracy in terms of celiac disease. Endomysial antibody testing and deamidated gliadin antibody testing also play a role in the testing for celiac disease; however, gliadin IgA and gliadin IgG antibodies have no role at this time in the testing for celiac disease.

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Comparison of Serological Tests

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Jump to section:

• Introduction
• Case 1: Negative Serology for Celiac Disease
• Limitations of Serology
• Case 2: Symptomatic Malabsorption
• Biopsy First?
• Comparison of Serological Tests
• Comparison of Serological Tests
• Marsh Classification
• Autoimmune Enteropathy²
• Autoimmune Enteropathy²
• False-Positive Biopsies
• False-Positive Biopsies
• Minimal Disease: Uncertain Histology
• Lymphocytic Duodenosis⁴
• Patient Presenting on Gluten-free Diet
• What About Patients on Gluten-free Diet?
• Gluten Challenge Testing
• Celiac Disease and HLA Risk
• Genetic Tests-Big Limitation⁵
• References
• Questions?